Formulation and Evaluation of Orphenadrine Citrate as a Model Drug for Topical Hydrogel

Authors

  • H. M. Suza Ali College of Pharmacy, Uruk University, Baghdad, Iraq.
  • B. A. Kamal College of Pharmacy, Osol Aldeen University, Baghdad, Iraq.
  • N. A. Abdalrazaq College of Pharmacy, Uruk University, Baghdad, Iraq.
  • H. M. Mohammed College of Pharmacy, Uruk University, Baghdad, Iraq.

Orphenadrine Citrate is a muscle relaxant, act as an anti- cholinergic drug and used in the treatment of Parkinson’s disease.  The objective of this study was to design a topical hydrogel formulation using Orphenadrine Citrate as a model drug. The topical administration is an alternative route that can minimize the side effects and may improve patient drug delivery. Different formulas were prepared using different gelling agents with different concentrations, CMC (1, 2 and 3% w/w), Xanthan gum (0.5, 1 and 1.5% w/w) and HPMC K40 (2, 2.5 and 3% w/w). The prepared formulas were evaluated for physical appearance, pH, Spreadability, drug content, viscosity besides to in- vitro drug release.  All the formulas prepared had acceptable hydrogel texture, increased viscosity as the gelling agent concentration increased, while spreadability decreased; in addition the pH hydrogel surface of the formulas showed within acceptable pH of skin.  On the other hand, among the polymer hydrogel used, it was found that xanthan gum gave (98.3%) Orphenadrine citrate release within 90 minutes while other polymers CMC and HPMC K40 gel was 70% and 62.6% drug release respectively within 90 minutes.   Finally, F6 was the optimum formula due to its acceptable hydrogel surface pH (6.7), good spreadability (4.4 cm2) and 98.3% Orphenadrine citrate release from the hydrogel.

Keywords:

Orphenadrine citrate, Hydrogel, Carboxy methyl cellulose, Xanthan gum, Hydroxy propyl methyl cellulose K40

[1] Sebaiy M M, El- Adi S M, Mattar A A, Elgawish M S. Simultaneous determination of paracetamol and orphenadrine cirtate in rat plasma using lc- MS/MS spectrophotometry method : pharmacokinetics and drug- drug interaction profile studies. Research square. 2022; 1: 1- 20. DOI: https://doi.org/10.21203/rs.3.rs-1567448/v1

[2] USP37 NF32. 2014; l.

[3] De Arauge, D.R.; Padula, C. Topical drug delivery: innovative controlled release systems. Pharmaceutics 2023, 25, 1761. DOI: https://doi.org/10.3390/pharmaceutics15061716

[4] Malpure PS et al., A Review on- hydrogel. American journal of pharmtech research, 2018; 8 (3). 1-21.

[5] Mishara KV, Tripathi SS. Formulation development and evaluation of gliclazide using water soluble sodium carboxy methyl cellulose polymer. Indian journal of research in pharmacy and biotechnology. 2013; 1(5): 697- 700.

[6] Hashim A, Kamal A B, Formulation and evaluation of acyclovire as buccal adhesive hydrogel, journal of science, 2015; 5: 1447- 1452.

[7] Hammoudi Z M, Ghareeb M M, Mahde B W. Preperation and characterization of topical cetrizene hydrochloride hydrogel. Int.J.Res.Pharm.Sci. 2018; 9(3): 510- 514. DOI: https://doi.org/10.26452/ijrps.v9i3.1529

[8] Suzle- Musiol B, Siemiradzaka W, Dolinska B. Formulation and evaluation of hydrogels based on sodium alginate and cellulose deriveives with quercetine for topical application. Appl. Sci. 2023; 13: 7826. DOI: https://doi.org/10.3390/app13137826

[9] Abbas M M, Rajab N A. Preparation and characterization of etodolac as a topical nanosponges hydrogel. Iraq j pharm Sci, 2019: 28 (1). DOI: http://doi.org/10.31351/vol28iss1pp64-74

[10] Singh V, Chaubey N. Design and evaluation of topical hydrogel formulation of aceclofenac for improved therapy. Journal of Drug Delivery & Therapeutics. 2019; 9(5):118-122. http://dx.doi.org/10.22270/jddt.v9i5.3605

[11] Abdel- Aziz B I, Rajab N R. Preperation and in- vitro evaluation of mucoadhesive clotrimazole vaginal hydrogel. Iraqi journal of pharmaceutical scince. 2014; 23(1).

[12] Maysam A M, Rajab N R. Preparation and characterization of etodolac as a topical nanosponges Hydrogel. Iraqi J Pharm Sci. 2019; 28 (1). DOI: https://doi.org/10.31351/vol28iss1pp64-74 64

[13] Clarke’s analysis of drug and poisons, fourth edition, volume 2, London, The pharmaceutical press 2011, p 1827- 1828.

[14] Thamer A K, Abood AN. Preparation and in- vitro characterization of aceclofenac nanosuspension (ACNS) for enhancement of percutaneous absorption using hydrogel dosage form. Iraqi J Pharm Sci. 2021; 30(2): 86- 98. DOI: https://doi.org/10.31351/vol30iss2pp86-98

[15] Masheshwari M M, Mali A, Paradkar A, Yamamuva S, Kadam S. Development of tetracyclin periodontal gel: formulation and preliminary clinical study. AAPS pham. Sci tech. 2006; 7(3): 76.

[16] Senhal P. Mulye, Kiran A, Wadkar S K. Formulation development and evaluation f indomethacin emulgel. Der pharmacia sinica. 2013: 4(5): 31- 45.

[17] Chaudhary B, Verma S. Preperation and evaluation of novel in- situ gels containing acyclovir for the treatment of oral herpes simplex virus infections. The scientific world journal. 2014; 1-7.

[18] Ashames A et al. Synthesis of cross- linked carboxymethyl cellulose and poly (2-nacrylamido- 2-methylpropane sulfonic acid) hydrogel for sustained drug release optimized by box- behnken design. Journal of Saudia chemical society. 2022; 26: 1-14. DOI: https://doi.org/10.1016/j.jscs.2022.101541

[19] Goci E, Haloci E, Xhulaj S, Malaj L. Formulation and invitro evaluation of diclofenac sodium gel. International journal of pharmacy and pharmaceutical sciences. 2014; 6.

[20] Trinaksis F, Robinson J R. Rheological mucoadhesive and release properties of hydrophilic polymers mixed gel system. 2005; 60(7): 518- 523.

[21] Neamah AJ. Rashid A M, Ghareeb M M. Eutectic Mixtures: A Promising Solvent in Drug Delivery System. ma'aen journal for medical sciences 2022;1:53e62. https://doi.org/10.55810/2789-9136.1010

[22] Khafeef K H, Rajab N A. Eplerenone Crystal Nanosuspension for Solubility Enhancement: Preparation and Evaluation. ma'aen journal for medical sciences. 2023; 2: 73- 80. https://doi.org/10.55810/2789-9136.1024

[23] Suza Ali et al. A Review article: Topical Drug Delivery System (Skin). Journal port Science research. 2024; 7: 558- 563. DOI: 10.36371/port.2024.special.44

[24] Abu Tbeekh H T, Mosa H A, Alsunboli M H. Efficacy of Verapamil Combined with Zinc Oxide for Anal FissureManagement. Journal port Science Research. 2024: 7. 10.36371/port.2024.special.42

[25] Al-Qaisy, Y., Arif, I. and Al-Ezzi, M., 2021. New Perceptions in the Cardioprotective Effect of Metformin Against Isoproterenol Induced Cardiotoxicity in Male Rats.Journal port Science Research, 4(1), pp.27-34. https://doi.org/10.36371/port.2021.6

[26] Al-Jeboory, A. and Farid, Y., 2021. Natural Product Chemistry Research in Iraq.Journal port Science Research, 4(1), pp41-45. 10.36371/port.2021.1.8

[27] Rafid M. Hashim, Yahya Y. Z. Farid, Synthesis, In Silico Study and Anti-Inflammatory Evaluation of New Ketoprofen Thiourea Derivatives.Journal port Science Research, 7(1), pp.69-76. https://doi.org/10.36371/port.2024.1.9

Formulation and Evaluation of Orphenadrine Citrate as a Model Drug for Topical Hydrogel. (2025). Journal Port Science Research, 8(1), 54-61. https://doi.org/10.36371/port.2025.1.10

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Formulation and Evaluation of Orphenadrine Citrate as a Model Drug for Topical Hydrogel. (2025). Journal Port Science Research, 8(1), 54-61. https://doi.org/10.36371/port.2025.1.10